| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.186 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of multi-layers Small Intestinal Submucosa (SIS) Sheet for Wound healing |
| 초록 | The main effect of most skin substitutes is to promote wound healing by stimulating the host to produce various cytokines. These cytokines promote healing by stimulating the production of cmoponents in the basement membrane, so preventing dehydration and increasing inflammation, and promoting the formation of granulation tissue. Porcinal small intestinal submucosa (SIS) has been shown to be rich in components which support angiogenesis such as fibronectin, glycosaminoglycans, several collagens and angiogenic growth factors which induce site-specific tissue remodeling. The wound improves healing activity and feels comfortable when the wound area shows the weak acidity. So, for SIS sheets having the weak acidity, we prepared SIS sheets swelled by 1% acetic acid with shaking for 24 hours at room temperature. And until the pH of DW was about 5.5, SIS sheets were washed by DW over 10 times. For multi-layer SIS sheets, SIS sheets were piled up another SIS sheets. And we prepared SIS sheets by spreading and freeze-drying. The prepared SIS sheets were evaluated their characteristics such as water uptake ability in various buffers, surface morphology and moisture vapor transmission rate. From this study, SIS is regarded as an appropriate biodegradable material able to dress the wound like a burn in substitution of the traditional artificial composite materials the expected to be used as the biological dressings. Key Words : small intestinal submucosa, multi-layer, swelling Acknowledgement : This work was supported by KMCIE(N11-A08-1402-05-1-3). |
| 저자 | 김선화1, 신혜원1, 장지욱2, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | small intestinal submucosa; multi-layer; swelling |
