| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Reinforced Tissue Adhesiveness of Cyclodextrin Incorporated Gelatin Bioglues |
| 초록 |
Bioglues are becoming promising materials in diverse clinical applications. However, to satisfy clinical requirements, the adhesiveness and biocompatibility have to be improved. In this study, Cyclodextrin (CD) incorporated gelatin-hydroxyphenyl (GH) hydrogels as a bioglue were developed to enhance the tissue adhesion property. The tissue adhesive strength of GH/CD hydrogels were significantly increased by incorporating CD into GH hydrogels via supramolecular forces. At GH 5 wt% and CD 5 wt%, the composite hydrogels exhibited maximum adhesive strength (36.5 kPa), which was nearly 3.3 and 8 times higher than that of GH hydrogels and fibrin glue as a control, respectively. Through in vitro cell study, we also confirmed that the GH/CD composite hydrogels have an excellent cytocompatibility. This shows an emerging potential as a promising tissue adhesive material. |
| 저자 |
이시민1, Thai Thanh Hoang Thi1, 이윤기1, 박경민2, 박기동1
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| 소속 |
1아주대, 2인천대 |
| 키워드 |
Bioglues; Supramolecular forces; GH/CD; adhesiveness
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| E-Mail |
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