| 초록 |
The purpose of this study was to investigate the drug release characteristics of tear protein component and ionic functional group at the physiological pH of tears. Hydrogel contact lenses were prepared by mixing HEMA and an ionic functional group (-VP, -NIPAAm) with a crosslinking agent EGDMA and initiator AIBN. The drug release behavior was observed at the physiological pH (5.8~8.35) of tears. The drug release of the ionic lens appeared to be the same as the increase and decrease of the water content of the lens. Characteristically, the water content of the lens was highest in the albumin solution, but cumulative drug release in the PBS solution was increased up to 7 times over the entire release time. This implies that, during the collapse of the buffering action to maintain normal range in tear to physiological pH change, the imbalance of tear protein such as albumin and lysozyme may sensitize metabolism and drug delivery between lenses do. |
