| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 |
25권 2호, p.2158 |
| 발표분야 |
제16회 약물전달 및 화장품 기술 심포지엄 (공업화학부문위원회) |
| 제목 |
Bioconjugation and Self-Assembly Technologies for Multi-Functional Biologics |
| 초록 |
Pharmaceutical industry has witnessed a growing number of biomolecular entities in competition with synthetic small molecules. Excellent target specificity and safety margin of biologics over small molecules are fueling such advancement. Recently, drug discovery efforts are in active transformation towards combining multiple preexisting biologics into a single molecular entity to achieve a higher efficacy and safety. In order to construct such multifunctional biologics, chemical and biomolecular toolkits have been developed. The bioconjugation covalently interlocks two different molecules directly or through a chemical linker. Bioorthogonal reactions developed to increase the site-specificity and the conjugation yield help produce chemically well-defined multifunctional biologics. The self-assembly utilizes a pair of peptidyl domains that non-covalently but specifically associate with each other to tether multiple biomolecules into a hybrid agent. I will review recent technological advances, and applications thereof for construction of multi-functional biologics. |
| 저자 |
임성인 |
| 소속 |
부경대 |
| 키워드 |
Biologics; Bioconjugation; Self-assembly; Multi-functional
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
