| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Theranostic approaches to cancer diagnosis and therapy using gas-generating nanoparticles |
| 초록 |
Theragnosis is an emerging approach that can perform diagnosis and therapy simultaneously, and has shown great potential in cancer diagnosis and therapy. Polymeric nanoparticles typically can encapsulate anti-cancer drugs as well as imaging probes. The aim of this research is to fabricate gas-generating nanoparticles that can be delivered to the tumor site and provide cancer-specific ultrasound imaging and necrotic cell death by generating gas bubbles. Gas-generating nanoparticles containing calcium carbonate minerals were fabricated by a W/O/W double emulsion method, followed by chemical modification with RVG peptide to target neuroblastoma. Various characteristics such as size, morphology, gas generation, and cytotoxicity of gas-generating nanoparticles were investigated in vitro. Gas-generating nanoparticles were useful to acquire cancer-specific ultrasonic images and reduced the tumor size in a tumor-bearing mouse model after intravenous administration. |
| 저자 |
조민영1, 이장욱1, 민현수2, 김광명2, 권익찬2, 이근용1
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| 소속 |
1한양대, 2한국과학기술(연) |
| 키워드 |
Gas-generating nanoparticles; ultrasonic imaging; tumor necrosis; calcium carbonate; PLGA
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| E-Mail |
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