| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication of Surface Functionalized Adenovirus Nano-Carriers for Intravascular Injection |
| 초록 |
Surface functionalized ADV nano-carriers with low-molecular chitosan (LMC), polyethyleneglycol (PEG), and FA were fabricated successfully by electrospinning method for intravascular injection. At first, pristine ADV was encapsulated with LMC by using electrospinning method. The size of the LMC coated ADV (ADV-cLMC) is about 70 nm. To confirm the LMC coating of pristine ADV, surface charges of pristine ADV and ADV-cLMC were measured by ζ-potential analysis. The ζ-potential of ADV and ADV-cLMC were -5 ± 2 mV and 3.3 ± 2 mV, respectively. Morphology of the ADV-cLMC was observed by transmission electron microscope (TEM). In the second step, PEG-FA synthesized in advance was conjugated with ADV-cLMC. The PEG-FA conjugated ADV-cLMC (ADV-cLMC-PEG-FA, ADV-LCPF) exhibited long circulation time and high solubility due to PEG conjugation. The surface functionalized ADV nano-carriers also had cancer targeting moiety due to FA modification. |
| 저자 |
박연아, 황태원, 김평환, 박홍관, 이정민, 윤채옥, 김중현
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| 소속 |
연세대 |
| 키워드 |
virus delivery; cancer targeting; intravascular injection; electrospinning; adenovirus; low-molecular chitosan
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| E-Mail |
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