| 초록 |
Spherical mesoporous silica particles were synthesized through sol-gel reaction with a cationic surfactant, an amphiphilic organotriethoxysilane, and TEOS. The amphiphilic organotriethoxysilane had a thermally reversible urethane bond. It acted as a surfactant in the gelation with tetraethoxysilane, forming a micellar structure, where the hydrophobic portion was located inside the micelle. The external surface of the silica particle was modified by PEG with a folic acid moiety at the end which could be used for cancer targeting. PEG was expected to improve the biocompatibility of the particle. The thermally reversible urethane bond of the amphiphile was dissociated to produce isocyanate functionality tethered to the inside pore wall by heating. Doxorubicin was covalently introduced into the internal pores by using the isocyanate moiety. |
