| 초록 |
In this study, we report how cell morphology is affected by the nanoscale topography of underlying substrates and the applied electrical field. First, we fabricated vertical silicon nanowires (SiNWs) via metal-assisted chemical etching and deposited poly(3,4-ethylenedioxydithiophene) (PEDOT) on SiNWs by electrochemical polymerization. Subsequently, mouse embryonic fibroblast cells (NIH-3T3) were cultured on the bare and PEDOT -modified SiNW substrates, and cell viability and morphology were examined. In contrast to the flat and star-like morphologies of cells grown on the control flat substrates, those on the PEDOT -coated SiNW substrates exhibit three-dimensional and round morphologies as revealed by confocal fluorescence microscopy. We expect that our study contributes to a fundamental understanding of external stimuli-induced tissue regeneration and wound healing mechanism. |
