| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 |
25권 2호, p.2155 |
| 발표분야 |
고분자 유체와 생체소재의 과거와 현재, 그리고 미래 심포지엄 (고분자부문위원회) |
| 제목 |
Dual-ionic pH-sensitive copolymers for hydrogel and versatile biomedical applications |
| 초록 |
Controlled delivery of molecules in response to the microenvironment can influence the treatment. We developed a series of dual-ionic pH-sensitive poly(urethane amino sulfamethazine)-based random copolymer for the controlled release of various therapeutic agents. Owing to the unique characteristics of poly(urethane amino sulfamethazine), it exhibited a dual ionic pH-sensitive property in an aqueous solution. At high pH (~pH 8.5), the copolymer exhibited a negative charge and was water soluble due to the presence sulfamethazine groups. On the other hand, at low pH (~pH 5.0), the copolymer transformed to cationic due to the ionization of tertiary amine groups. Interestingly, at the physiological condition (pH 7.4), poly(urethane amino sulfamethazine) copolymer could form a particulate structure and encapsulate protein/drugs effectively via the ionic and hydrophobic interaction between polymer and protein/drugs. The dual-ionic pH-sensitive characteristics of the copolymers were used in the controlled delivery of protein/drugs to treat various intractable diseases. |
| 저자 |
이두성 |
| 소속 |
진단/치료용 고분자소재 연구센터 / 성균관대 |
| 키워드 |
Dual-ionic copolymer; pH-sensitive; hydrogel; biomedical application
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| E-Mail |
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| 원문파일 |
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