| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Molecular Effect of PVP on The Release Property of Carvedilol Solid Dispersion |
| 초록 |
Solid dispersion (SD) improved solubility and bioavailability of insoluble drug. This study aimed to confirm the effect of molecular weight in SD of carvedilol with PVP. Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of SD. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of SD. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of SD. DSC and XRD show that drug crystalline was changed. FT-IR revealed that chemical structure of SD comparing the chemical structure of drug was changed. The dissolution studies of SD presented at simulated gastric juice (pH 1.2). The dissolution rate of SD was dramatically enhanced than pure drug and the molecular weight of PVP has an effect on the release property of carvedilol in SD. This research was supported by WCU (R31-20029). |
| 저자 |
이정근, 심정보, 유한나, 이가영, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
solid dispersion; carvedilol; PVP; molecular weight
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| E-Mail |
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