| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-콜로이드·계면화학 |
| 제목 |
Goldnanorods-encapsulated thermosensitive drug carriers for NIR light-responsive cancer therapy |
| 초록 |
Thermoresponsive polymers incorporated with photo-absorbing agents have been widely used for controlled drug delivery using light. However, conventionally developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In a recent study, gold nanorods (GNRs)-encapsulated PVCL(GNR-PVCL) particles were synthesized by SFL method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, that could allow for localized injection. To achieve NIR light-responsive cancer therapy, Doxorubicin(DOX) was encapsulated into GNR-PVCL microparticles. These particles exhibited NIR triggered drug release due to the photothermal effect of GNRs. We also demonstrated efficient intracellular release and anticancer activity of DOX upon NIR exposure. This study demonstrates that DOX-GNR-PVCL microparticles have substantial potential as implantable drug carriers enabling NIR triggered drug release. |
| 저자 |
노윤호1, 엄지연1, 최대건2, 문주연1, 김도연1, 심민석2, 봉기완1
|
| 소속 |
1고려대, 2인천대 |
| 키워드 |
Stop-flow lithography; Gold nanorod; NIR light; Photothermal effect; Cancer therapy
|
| E-Mail |
|
