| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-콜로이드·계면화학 |
| 제목 | Novel angiogenic metal nanoparticles controlling intracellular gene activation in stem cells |
| 초록 | Metal and oxide nanoparticles (NPs) are attracting extensive attention inbiomedical applications, including bioimaging and drug delivery. However, it isdifficult to use these NPs as therapeutic agents for specific cell and tissuetreatments because of limitations such as material oxidization and celltoxicity. Herein, we synthesized Cu based angiogenic metal nanoparticles(Cu-AMNs), using a galvanic replacement reaction of Cu NPs and Au precursor,which stabilized and upregulated intracellular behaviors in humanadipose-derived stem cells (hADSCs). Our novel therapeutic Cu-AMNs showedremarkable advantages in cell treatment, such as low mitochondrial damage,reduced ATP consumption, decreased cytotoxicity, and improved hypoxia induciblefactor-1 alpha (HIF1α) expression. In addition, Cu-AMNs improved otherangiogenic factors and the amount of exocytosed Cu from hADSCs, resulting instrong development of tubular formation by human umbilical vein endothelialcells in vitro. |
| 저자 | 송지우, 유태경, 이재영 |
| 소속 | 경희대 |
| 키워드 | Angiogenesis; Controlled release; Copper nanoparticle; Endo(Exo)cytosis; Stem cell |
