| 초록 |
Skin penetrating peptides (SPPs) are widely studied as a non-invasive strategy for transdermal delivery. However, systematic studies on the skin penetration mechanism and bio-effect evaluation of SPPs is insufficient. In this study, we quantitatively evaluated the skin permeability and bio-effects of SPPs-conjugated bioactive peptides using living reconstructed human skin equivalents including dermal layer and epidermal layer. Various types of SPPs were designed and synthesized according to molecular weight, isoelectric point, charge, hydrophilicity, hydrophobicity. The living reconstructed human skin equivalents were fabricated to evaluate the skin penetrating mechanism and bio-impact factors simultaneously. Overall, this SPPs with different characteristics would be actively used in tissue engineering, drug delivery, and cosmeceuticals. |
