| 초록 |
The hydrogels are widely used for drug delivery. Their uses as a carrier depend on controlling the structures and mechanical properties. However, conventional strategies have limitations, such as initial burst and release rate of encapsulated materials. To solve this limitation, we hypothesized that the functional self-assemblies composed of chemically cross-linking units and physically assembling moieties would exhibit decreased initial burst and sustained release. First, the bio-inspired oligo(L-valine)-based amphiphilic copolymers, acrylated poly(ethylene glycol)-b-oligo(L-valine) were successfully synthesized to form self-assemblies in an aqueous solution. Then, the gel was prepared by varying of molecular weights and their concentrations and we evaluated the protein release profile. We demonstrated that self-assemblies in gel could induce sustained release and mechanical force-triggered release. Finally, this strategy will be useful to control the hydrogel as delivery carriers. |
