| 학회 |
한국재료학회 |
| 학술대회 |
2013년 봄 (05/23 ~ 05/24, 여수 엠블호텔(THE MVL)) |
| 권호 |
19권 1호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Effect of Cross linking by Gamma Radiation on Sodium Carboxyl Methyl Cellulose-Gelatin-BCP Hydrogel for bone tissue engineering |
| 초록 |
To meet the demand of bone regeneration due to fracture or disease, there are many reports on the fabrication of bone substitutes which are combined with bio-ceramics and bio-polymer. In this work, nanoparticles BCP powder loaded sodium carboxyl methyl cellulose-gelatin (NaCMC-Gel) hydrogel scaffold was fabricated by freeze-drying successfully. Especially, the effect of cross linking of cellulose-gelatin hydrogel by physical (gamma radiation) approaches was focused. The hydrogel was freeze-dried for making the assembly a seamless porous scaffold. This scaffold maintained the well-defined compressive mechanical strength and porosity which is helpful for bone regenerating and thus the faster healing is possible. Detailed morphological and material characterizations such as compressive strength, porosity, microstructure analysis were carried out. MTT assay, confocal imaging were carried out as in vitro experiments to observe the cell attachment, proliferation and differentiation with pre-osteoblast MC3T3-E1. |
| 저자 |
Avik Sarker1, Nguyen Thuy Ba Linh2, Hyoung Seok Kim3, Yeo Woori Lee4, Byong Taek Lee5, Youn-Mook Lim6
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| 소속 |
1Department of Biomedical Engineering and Materials, 2Institute of Tissue Regeneration, 3College of Medicine, 4Soonchunhyang Univ., 5Cheonan City, 6Chungnam 330090 |
| 키워드 |
sodium carboxylmethylcellulose-gelatin; gamma radiation; confocal imaging
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| E-Mail |
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