| 초록 |
Migration of cells along the right direction is of paramount importance in a number of in vivo circumstances such as immune response, embryonic developments, morphogenesis, and healing of wounds and scars. It has been known that the directed migration of cells occurs only in the presence of a spatial gradient in the magnitude of bio-signals, for examples, concentration of soluble chemicals, density of adhesion ligand, and stiffness of extracellular matrix (ECM). In this study we generate the hydrogel substrate for 2D cell culture with independently controlled spatial gradients of matrix stiffness and density of adhesion ligand. Future studies will be aimed at understanding how each spatial gradient competitively and/or cooperatively influences a direction and a speed of cell migration. |
