| 초록 |
Porous Poly(3-hydroxybutyrate) (PHB) scaffolds were prepared by the non-solvent-induced phase separation method using chloroform as a solvent and tetrahydrofuran as a non-solvent. The influence of solvent composition and PHB concentration on the structure of PHB organogels and porous scaffolds were elucidated by small-angle neutron scattering as well as scanning electron microcopy analysis. Conformational changes of PHB chains during gelation were monitored in situ by time-dependent infrared spectral measurements. Applying solvent exchange and freeze-drying processes to the as-produced organogels allowed fabrication of nanofibrous PHB monoliths with high porosity (~97%) and surface areas up to 72.1 ± 0.6 m2/g. It was shown that by varying the solvent mixture composition and PHB concentration, the gelation kinetics, crystallization behavior, nanofibrous structure, pore character, surface area, and the mechanical properties of PHB aerogels, were effectively controlled. |
