| 초록 |
Graphene oxide has unique physiochemical properties, showing great potentials in biomedical applications. In this work, functionalized reduced graphene oxide (PEG-BPEI-rGO) has been developed as a nanotemplate for photothermally triggered cytosolic drug delivery by inducing endosomal disruption and subsequent drug release. PEG-BPEI-rGO has ability to load more amount of Doxorubicin(DOX) than unreduced PEG-BPEI-GO. Loaded DOX could be efficiently released by glutathione (GSH). Importantly, PEG-BPEI-rGO/DOX complex was found to escape from endosome after cellular uptake by photothermally induced endosomal disruption, followed by GSH-induced DOX release into cytosol. This study demonstrated the development of the potential of PEG-BPEI-rGO nanocarrier by photothermally triggered cytosolic drug delivery via endosomal disruption |
