| 초록 |
Owing to the tumor-targeted migration capacity of human mesenchymal stem cells (hMSCs), they have been combined with nanoparticles for photothermal therapy. However, the low viability of hMSCs following transplantation remains a problem. We developed iron ion-releasing gold nanoparticles (IIAuNPs) for photothermal therapy using hMSCs. IIAuNPs were designed to undergo degradation under low pH conditions, such as the endosomal microenvironment, for Fe ion release in hMSCs. In vitro cell migration and anti-apoptotic factor secretion were observed. IIAuNPs-treated hMSCs were intravenously injected into tumor-bearing mice, and enhanced tumor targeting based on improved cell viability and cell migration was evaluated. IIAuNPs-treated hMSCs showed enhanced tumor-targeting efficiency and subsequent photothermal effect compared to hMSCs without IIAuNP treatment. Our results suggest that metal-ion-releasing nanoparticles may provide a promising platform for future photothermal therapies. |
