| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.343 |
| 발표분야 |
생물화공 |
| 제목 |
Localized injectable drugs delivery hydroxyapatite microspheres for osteoporosis therapy |
| 초록 |
This study describes the preparation of hydroxyapatite microspheres for local drugs delivery. The formation of the hydroxyapatite microspheres were initiated by enzymatic decomposition of urea and accomplished by emulsification process (water-in-oil). The microspheres obtained were sintered at 500℃. Scanning electron microscope (SEM) indicated that the microspheres have various porous with random size, which maximizes the surface area. Cytotoxicity was not observed after sintering. Osteoporosis drugs, alendronate and BMP-2, were loaded into HAp microspheres and the releases of both molecules showed sustained releasing profiles. Finally, animal trial was performed to justify all the involved concerns to develop in vivo drug carrier. |
| 저자 |
이진형1, 고일환1, 전성현2, 채지화2, 이은정2, 장정호1
|
| 소속 |
1한국세라믹기술원, 2한스바이오메드(주) |
| 키워드 |
drug delivery; hydroxyapatite; osteoporosis; localized drug carrier; bone engineering
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
