| 학회 |
한국화학공학회 |
| 학술대회 |
2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 |
9권 2호, p.1598 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis of Thermosensitive Block Copolymers and Theirs Physicochemical Properties |
| 초록 |
The synthesis and characteristics of amphiphilic block copolymers have been much interest because of he unique molecular architecture and different chemical nature. AB-type block copolymers having both hydrophilic and hydrophobic segments are known to form micellar structures in aqueous media due to their amphiphilic character. Polymeric micelles maintain their satisfactory aqueous stability irrespective of the high content of hydrophobic drug bound within the micelle inner core. In this study, the well-defined poly(N-isopropylacrylamide)(PNIPAAm)/poly(ε-caprolactone)(PCL) diblock copolymers were synthesized through combining radical polymerization of NIPPAAm and the controlled coordination-insertion ring-opening polymerization of CL. Molecular characterization of PNIPAAm/PCL diblock copolymers was confirmed through 1H-NMR, FT-IR and GPC analysis. Polymeric micelles composed of PCL as a hydrophobic core and PNIPAAm as a hydrophilic shell were prepared by a diafiltration method. The sizes and shapes of the thermosensitive micelles were investigated with a AFM. |
| 저자 |
최창용1, 김태형1, 정택웅2, 나재운1
|
| 소속 |
1순천대, 2한국기초과학(연) |
| 키워드 |
Thermosensitive;block copolymer;nanoaprticle |
| E-Mail |
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| 원문파일 |
초록 보기 |
