| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 |
28권 2호, p.163 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of Thermosensitive Block Copolymer and Preparation and Characterization of Theirs Micelles |
| 초록 |
The synthesis and characteristics of amphiphilic block copolymers have been much interest because of he unique molecular architecture and different chemical nature. AB-type block copolymers having both hydrophilic and hydrophobic segments are known to form micellar structures in aqueous media due to their amphiphilic character. Polymeric micelles maintain their satisfactory aqueous stability irrespective of the high content of hydrophobic drug bound within the micelle inner core. In this study, the well-defined poly(N-isopropylacrylamide)(PNIPAAm)/poly(ε-caprolactone)(PCL) diblock copolymers were synthesized through combining radical polymerization of NIPPAAm and the controlled coordination-insertion ring-opening polymerization of CL. Molecular characterization of PNIPAAm/PCL diblock copolymers was confirmed through 1H-NMR spectrophotometer, FT-IR spectrophotometer and gel permeation chromatograhp analysis. Polymeric micelles composed of PCL as a hydrophobic core and PNIPAAm as a hydrophilic shell were prepared by a diafiltration method. The sizes and shapes of the thermosensitive micelles were investigated with a atomic-force microscope. |
| 저자 |
최창용1, 김태형1, 정택웅2, 나재운1
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| 소속 |
1순천대, 2한국기초과학(연) |
| 키워드 |
thermosensitive; block copolymer; nanoparticle
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| E-Mail |
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