| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | In vivo evaluations of RGD-conjugated MPEG-PCL on bone regeneration using rabbit calvarial model |
| 초록 | In this study, we aimed to develop an injectable RGD-immobilized MPEG-PCL (MPEG-PCL-RGD) hydrogels that are capable of controlling osteogenesis and regeneration. In animal studies, rabbits were created on four calvarial defects in each animals. Bone formation was estimated by using three kinds of implants in MPEG-PCL alone, MEPG-PCL-0.8mM RGD/MSC, and MPEG-PCL-2.4mM RGD/MSC. Bone regeneration was evaluated using X-ray, micro CT and histology for up to six weeks. In MSC seeded MPEG-PCL-RGD treated group, the new bone formed from the margin of the defect. In comparison, MSC seeded MPEG-PCL control group showed bone formation from the periphery of the defect with low density. These data suggests that MPEG-PCL-RGD presents stability of MSCs and enhanced bone regeneration in rabbit calvarial defects. Acknowledgment : This research was supported by the grant of ministry of Trade, Industry and Energy(MOTIE) (Grant no. 10047811) |
| 저자 | 김현주, 양대혁, 유수정, 전흥재 |
| 소속 | 가톨릭대 |
| 키워드 | MPEG-PCL; RGD; calvarial defects; bone regeneration |
