| 초록 |
Cell spheroids have been studied as biomimetic medicine for tissue healing using cellular sources. Rapid cell spheroid production shortens processing time, increasing cell viability and activity as well as efficiency of mass production. In this study, two-dimensional MXene (Ti3C2) particles were used to form mesenchymal stem cell spheroids, and during this process, the optimal MXene concentration, spheroid formation time, and bioactivity level of spheroid cells were evaluated. MXene concentrations ranging from 1 to 10 µg/mL induced spheroid formation within 6 h. MXene-induced spheroids exhibited osteogenic differentiation behavior with the highest activity level at a concentration of 5 μg/mL. We report a novel and effective method for the rapid formation of stem cell spheroids using MXene. |
