| 초록 |
Over the past few decades, various methods have been studied to enhanced photodynamic effects for cancer treatment. Most photodyanamic therapy (PDT) use high energy light as a light source due to photosensitizers (PS). There is a problem that the light can not penetrate deeply into the cell. Howover, by converting low-energy light into high-energy light, the depth of cell penetration can be deeply controlled. In this study, upconversion nanoparticles (UCNPs) with hexagonal phase were synthesized by hydrothermal method. Then, biocompatible block copolymer with targeting ligand were introduced into the UCNPs for surface modification and also PSs were conjugated for PDT action. Their morphology, chemical composition and optical properties were analyzed. In addition, in vitro cell viability and cellular uptake were determined using MCF7 and A549 cells. |
