| 초록 |
Shell cross-linking of polymer micelles is recognized as a good approach to stabilize micelles by suppressing the dissociation even at a diluted condition. For drug delivery, however, shell cross-linkers should be cleaved to deliver entrapped drugs at target tissues. Thus, one of promising approaches is to use crosslinkers cleavable in response to specific intracellular signals. In this work, we describe glutathione-mediated controlled drug release from shell cross-linked polymer micelles. The middle shells of PEG-b-PLys-b-PPhe micelles were cross-linked using disulfide crosslinkers. The drug release was retarded at extracellular conditions due to the maintenance of disulfide linkages of crosslinkers. On the other hand, the high glutathione level of intracellular conditions triggered the accelerated drug release by reducing disulfide bonds of crosslinkers. Polymer micelles with glutathione-cleavable crosslinkers can serve as a useful intracellular carrier of many bioactive agents. |
