| 초록 |
Biocompatible polymers have been employed as a macromolecular excipient that can encapsulate the toxic drugs to reduce the unfavorable side effects. However, these excipients have commonly shown detrimental toxicity and poor stability. To overcome such drawbacks, we have prepared a series of block-copolymers composed of PEG and PAA via controlled radical polymerizations. The resulting copolymers were employed to incorporate the cisplatin pharmacophore (PtII), a well-known anticancer agent, which then leads to the formation of self-assembled core-shell type nanostructures in aqueous media. By varying the composition of core-forming PAA blocks and PEG chains on the shell, the resulting colloidal structures were remarkably changed, showing the significantly altered cmc’s and agitation time required for the PtII-mediated nanoparticle formation. In this talk, their physicochemical characterizations and the polymeric structure-related colloidal properties will be discussed. |
