| 초록 |
Polymer cubosome is a highly ordered periodic porous polymer nanostructure with large-pore networks composed of inverse cubic mesophases of block copolymer bilayers. Due to its large surface area, it has a potential to be used in separation, drug delivery and nanotemplating by the introduction of functional groups on its surface. The structural requirements for self-assembly of block copolymers into polymer cubosomes requires the hydrophilic block to have a branched architecture. Herein, we describe the synthesis of branched-linear block copolymers having hydrophilic blocks composed of three poly(ethylene glycol)s with an alkyne end group. These block copolymers self-assemble in aqueous solution to provide polymer cubosomes with densely populated surface functional groups. To utilize the large surface area of functionalized polymer cubosomes as affinity-based separation of biomolecules, we introduced the Ni-NTA complex to the acetylene groups at the surface of polymer cubosomes. |
