| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Controlled Release of Solid Dispersed Pioglitazone HCl with Hydroxypropyl Methylcellulose viscosity |
| 초록 |
This study was carried out to find formation of solid dispersion for overcoming initial burst of pioglitazone HCl. Thus we prepared pioglitazone HCl solid dispersion as contents of polymeric material using spray dryer. HPMC is the most important hydrophilic carrier material used for the preparation of oral controlled drug delivery systems. One of its most important characteristics is the high swellability, which has a significant effect on the release kinetics of an incorporated drug. We analyzed surface of sample by scanning electron microscope(SEM) and X-ray diffraction(XRD) was used to analyze the crystallinity of the sample. Also the change of structure and crystallinity characteristic of solid dispersion tablet were analyzed by fourier-transform infrared spectoscopy(FT-IR). We prepared tablet with solid dispersion by direct compression and observed in vitro release behavior of solid dispersion from tablets in gastric juice(pH 1.2). |
| 저자 |
조한수, 김대성, 홍민성, 송병주, 홍동현, 유현, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Pioglitazone HCl; HPMC; solid dispersion; spray dryer
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| E-Mail |
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