| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Controlled release of drug using gold cluster-labeled liposomal doxorubicin into chitosan hydrogel by NIR irradiation for cancer therapy |
| 초록 |
Although liposomes has been widely studied as potential carrier for drug delivery systems, effective carrier system for controlled drug release is needed to achieve therapeutic efficacy. Therefore, we developed gold cluster-labeled thermosensitive liposomal doxorubicin (GTSL-DOX) entrapped into chitosan hydrogel (CH-HG) system for controlled release of drug by NIR irradiation. The size and surface charge of GTSL-DOX was 169 ± 6 nm and –50.5 ± 0.5 mV, respectively. Release of DOX from GTSL-DOX was increased depending on time under NIR irradiation (1.00 W/cm2) compared to non-NIR irradiation. Therapeutic efficacy of CH-HG containing GTSL-DOX combined with NIR irradiation resulted in significant inhibition of tumor growth compared to control (p ＜0.005 ) against B16F10 tumor model. Taken together, CH-HG containing GTSL-DOX has the potential for controlled drug release by NIR irradiation in tumor microenvironment. |
| 저자 |
원지은1, 위태인1, 이재명1, 박영민1, 신병철2, 한희동1
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| 소속 |
1건국대, 2한국화학(연) |
| 키워드 |
drug delivery; controlled release; liposome; nanoparticle
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| E-Mail |
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