| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | 입체선택적인 L-트레오-베타-벤질옥시아스팔틱 에시드의 합성 |
| 초록 | Glutamate is a major excitatory neurotransmitter and its concentration should be maintained precisely. Aspartate derivatives have known as a glutamate transporter inhibitor and considered to be responsible to control the concentration of glutamate. L-threo-β-benzyloxyaspartic acid (L-TBOA) is one of aspartate derivatives and its stereoselective synthetic methods have been reported. In this study, high stereoselective synthetic method for L-TBOA is introduced. By protecting α-amino aldehyde with N-hydroxymethyl group, stable α-amino aldehyde can be obtained. Then series of reactions to the stable α-amino aldehyde give threo-β-amino-α-hydroxy acid. Final O-benzylation presents L-TBOA. |
| 저자 | 이윤재, 서영란, 이보람, 김영규 |
| 소속 | 서울대 |
| 키워드 | L-TBOA; glutamate transporter inhibitor |
