| 초록 |
Gallol is a ubiquitous functional group found in plant polyphenols. Along with mussel-inspired adhesion chemistry, gallol-polymer conjugates have been emerging as biomaterials due to excellent adhesiveness and rapid oxidative crosslinking to prepare easily medical formulations. Here, we present unique properties of plant polyphenols and gallol-polymer conjugates for cardiac tissue targeting and advanced 3D printing. In the first topic, tannic acid – polyphenols which are widely found in plants – is spontaneously complexed with proteins for cardiac tissue targeting. In the second topic, the gallol-modification of extracellular matrix (ECM) components permits suitable viscoelasticity, good shape fidelity for 3D bioprinting and additional functionality such as ‘on-tissue printing’. Our findings for gallol-polymer conjugates would be applicablee to design biomedical formulations with cardiac tissue adhesion and mechanically tunable properties for advanced 3D printing. |
