| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vitro characterization and in vivo evaluation of catechin-eluting PLGA nanofiber membrane for application to anti-adhesion barrier |
| 초록 |
Nanofibrous poly(lactic-co-glycolic acid) (PLGA) hybrid membranes eluting epigallocatechin-3-O-gallate (EGCG), a main polyphenolic component of green tea, were prepared via electrospinning and then characterized to evaluate their application potential to tissue-adhesion barriers. EGCG-eluting PLGA (E-PLGA) nanofiber membranes showed sustained EGCG release by controlled diffusion and PLGA degradation. The attachment and proliferation of L-929 fibroblastic cells were significantly suppressed on E-PLGA membranes. The anti-adhesion efficacy study revealed that after 2 wk of surgical treatment, tissue adhesion score of E-PLGA nanofiber membranes was noticeably lower than that of non-treated or other commercialized tissue-adhesion barriers. In conclusion, the E-PLGA membranes may be exploited to craft strategies for the prevention of post-surgical adhesion formation. |
| 저자 |
한동욱1, 배기범2, 현승휴3
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| 소속 |
1부산대, 2인제대, 3Institute for Frontier Medical Sciences |
| 키워드 |
PLGA nanofiber membrane; EGCG; Anti-adhesion barrier
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| E-Mail |
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