| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Transdermal delivery of 5-FU using Microneedle |
| 초록 |
5-Fluorouracil (5-FU) is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time and strong side effects. Microneedle introduced for find a solution of problems. Microneedle device with roll was manufactured for transdermal delivery of various drugs. 5-FU was mixed in non-ionic surfactant such as tween 20 and tween 80. Camscope was used to analysis the permeation magnitude of treated skin by microneedle and trypan blue stanining. The 5-FU solution with surfactant measured by ELS-8000 for stability of solution. The skin permeation rate of 5-FU solution determined by HPLC. Treated skin is dyed deeply cross treated skin using the trypan blue against the parallel treatment. The results indicate that skin permeation rate of 5-FU was increased with the treatment types, treatment times and the treatment by microneedle. |
| 저자 |
김윤태, 이준희, 박종학, 안식일, 오아영, 강길선
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| 소속 |
전북대 |
| 키워드 |
Transdermal; 5-FU; Tween 20; Tween 80
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| E-Mail |
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