| 초록 |
MPEG-b-PCL with amphiphillic structure is attractive material for thermosensitive hydrogel systems due to its biodegradability and biocompatibility. In the study, we focused on the synthesis and the thermal phase transition behaviors of MPEG-b-PCL copolymers with ionic groups at the chain ends. The copolymers with ionic groups were successfully prepared and characterized with 1H NMR, DSC, XRD and GPC. The thermal phase transitions were measured according to the temperature variation. Introduction of different ionic end groups shifted the onset temperature of gelation, decreased the maximum viscosity, and stabilized the gel state over a slightly narrower temperature range than was observed for MPEG-b-PCL. These observations indicated that the crystallinity and hydrophobicity of the PCL blocks were critical to their thermal phase transition behavior. Consequently, we believe that MPEG-b-PCL copolymers with ionic groups could be utilized as a potential injectable drug and cell carrier. |
