| 초록 |
Despite three decades of research, nanomedicines have yet to provide a benefit to patients. A fundamental limitation of current approaches to nanomedicine delivery is that they lack capabilities of targeting amplification and tissue penetration of therapeutic agents. This presentation will discuss our recent approaches to leveraging biological systems to improve nanomedicine. First, we have developed drug delivery nanosystems where two distinct nanomaterials work in concert within the bloodstream to amplifiy tumor targeting and improve therapy in vivo, whch was mediated by heat-sensitive biological responses. Secondly, we have developed drug delivery nanosystems where extracellular vesicles in the tumor microenvironment, which are the innate biological transport system, were engineered in situ to improve tumor penetration of therapeutic compounds and their therapeutic efficacy. |
