| 초록 |
It has been a challenge to develop tissue adhesives with both biocompatibility and high adhesive strength. To achieve both properties simultaneously, in this study, tissue-adhesive materials are developed via the modification of chitosan with activated catechol derivatives. First, catechol derivatives are activated with pH and specific enzymes. Second, Chitosan backbone was modified with the activated catechol derivatives via various reactions. To optimize the balanced forces of cohesiveness and adhesiveness of the prepared materials, curing was controlled by the oxidation of catechol moieties, substitution degree, and metal coordination. The physicochemical property and adhesive strength of modified chitosan were characterized. In summary, our results demonstrate the potential of the modified chitosan at the type of matrix as an effective tissue-adhesive medical devices applicable in surgical operation. |
