| 초록 |
Glycol chitosan (GC) is a natural derivative polymer and have been widely used as a biomaterial due to its biodegradability, biocompatibility, antibacterial activity and enhanced solubility to neutral water. Moreover, continuous urge for new biomaterial leads to synthesis of GC derivatives with additional surface functionalities for different biomedical applications. In this study, we focused on conjugation of GC with gallic acid (GA, 3,4,5-trihydroxybenzoic acid), which is a natural phenolic acid from plant. Exhibiting antioxidant ability and antibacterial activity. We synthesized GA conjugated GC (GA-GC) via amide coupling between GC and GA. The degree of conjugation was determined by 1H NMR. Depending on feed molar ratio, the degree of conjugation was varied from 5 to 15. The successful synthesis of GA-GC was further confirmed by functional group peaks in ATR-FTIR spectrum and the presence of peak at 259 nm, indicative of aryl group, in UV-vis spectrum. |
