| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Heparin-induced sterically stabilized liposomes to prolong the circulation time in bloodstream after intravenous injection in mice |
| 초록 | In this study, sterically stabilized liposomes was prepared by heparin conjugation on the surface of doxorubicin-encapsulated liposomes in order to prolong the circulation time after intravenous injection in mice. Heparin has strong anionic charge and anticoagulant property,1 which renders it efficient fixation on the surface of cationic liposomes. The cationic liposomes was prepared by using dimethydioctadecylammonium (DDAB) as a cationic lipid. The heparin coated liposomes greatly improved the half-life in blood circulation while conventional liposomes showed marginal improvement (Fig. 1). Biodistribution of heparin conjugated liposomes indicated fewer uptake of heparin conjugated liposomes by the reticuloendothelial system, compared with conventional liposomes after intravenous injection in mice.2 Fig. 1. Circulation time of various liposomal doxorubicin formulations after intravenous injection in mice. References 1. A. Sahli, M. Cansell, J. Tapon-Bretaudiere, D. Letourneur, J. Jozefonvicz, Colloid Surf. B-Biointerfaces, 10, 205 (1998). 2. E. L. Riche, B. W. Erickson, M. J. Cho, J. Drug Target., 12, 355 (2004). |
| 저자 | 이애리, 한희동, 성하수, 신병철 |
| 소속 | 한국화학(연) |
| 키워드 | heparin; liposomes; circulation time; biodistribution |
