| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | An evaluation of comb-like poly(ethylene glycol) conjugated liposomes for long circulation in vivo |
| 초록 | In this study, comb-like poly(ethylene glycol) conjugated liposomes containing doxorubicin was prepared to prolong the circulation time in vivo. Comb-like poly(ethylene glycol) was composed of MMA, HPOEM and POEM.1 Circulation time in blood, biodistribution, and antitumor activity in vivo of modified liposomes were evaluated.2 Average particle size and encapsulation efficiency of modified liposomes were 81±1.3 nm and 93%, respectively. Modified liposomes showed longer half-life than those of conventional liposomes and free doxorubicin (Fig. 1). Biodistribution of modified liposomes in liver and spleen indicated fewer uptake by the reticuloendothelial system, comparing with conventional liposomes. Furthermore, antitumor activity of modified liposomes in vivo was enhanced, comparing with conventional liposomes. Fig. 1. Circulation time of various liposomal doxorubicin formulations after intravenous injection in mice. References 1. D. J. Irvine, A. M. Mayes, Biomacromolecules, 2, 85 (2001). 2. E. L. Riche, B. W. Erickson, M. J. Cho, J. Drug Target., 12, 355 (2004). |
| 저자 | 이애리, 한희동, 성하수, 신병철 |
| 소속 | 한국화학(연) |
| 키워드 | long circulation; comb-like poly(ethylene glycol); liposomes; biodistribution |
