| 학회 |
한국공업화학회 |
| 학술대회 |
2010년 봄 (05/13 ~ 05/14, BEXCO(부산)) |
| 권호 |
14권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Release kinetics of Doxorubicin from heparin-based self-assembled nanoparticle system |
| 초록 |
Current anticancer drug therapy results in systemic side effects due to nonspecific uptake by normal healthy noncancerous tissues. Therefore, the altered biodistribution of these drugs has an important meaning not only to reduce the toxicity but also to improve therapeutic effects. A Novel heparin-based nanoparticle system composed of folate-conjugated heparin/poly(β-benzyl-L-aspartate) (FHP) amphiphilic copolymers was developed to achieve targeted drug delivery for chemotherapy.Doxorubicin(DOX)-loaded FHP nanoparticles with high drug-loading content and efficiency were prepared. The DOX-loaded FHP nanoparticles displayed pH-dependent sustained release kinetics. |
| 저자 |
이립1, 허강무1, 이용규2, 김소연1
|
| 소속 |
1충남대, 2충주대 |
| 키워드 |
heparin; drug delivery; doxorubicin; nanoparticle
|
| E-Mail |
|
