| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Mussel-inspired, Ethylene Glycol-Derivatized Polydopamine for Antibacterial Coating |
| 초록 |
Biofilm that are made up of bacteria can cause severe medical infection and can be crucial problems for the implantable medical devices. The surface modification with non-biofouling materials has been recognized as one of effective approaches to inhibit biofilm formation. Inspired by mussel’s adhesive proteins, we synthesized a dopamine derivative via esterification of oligo(ethylene glycol) (OEG) with L-3,4-dihydroxyphenylalanine (L-DOPA). It is designed to have catechol and amine moieties for one-step, facile coating without any additives. OEG was selected to suppress the surface adsorption of bacteria. Titanium dioxide (TiO2) that has been widely used as a medical material was coated with the dopamine derivative (OEG-DOPA). The bacterial adhesion was investigated with gram-negative E.coli and minimal bacterial adhesion was achieved by oxidative polymerization of OEG-DOPA and catechol-Fe(III) coordination. |
| 저자 |
기소현, 이슬기, 송수정, 최준식, 조우경
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| 소속 |
충남대 |
| 키워드 |
Antibacterial coating; Oligo(ethylene glycol); Dopamine; Fe(III); Coordination
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| E-Mail |
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