| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Direct chemotherapeutic drug delivery system through an intratumoral drug depot |
| 초록 |
In this study, we describe an intratumoral injectable doxorubicin (DOX) and 5- fluorouracil (FU) to enhance the efficacy and reduce the toxicity of systemically administered Fu and Dox in cancer patients. The key concept in this work was the preparation of Dox-loaded microcapsules (Dox-M) and Fu-loaded pluronic hydrogels (Fu-HP) or Fu-loaded diblock copolymer hydrogel (Fu-HC) have been employed as drug depots. The Dox-M/Fu-HP and Dox-M/Fu-HC drug depots described in this work showed excellent performance as chemotherapeutic delivery systems. The results of this study indicate that intratumoral injection using combination chemotherapy with Dox-M/Fu-HP or Dox-M/Fu-HC drug depot describe in this study can synergistically enhance anticancer activity in chemotherapeutic delivery systems. |
| 저자 |
노정현, 박승훈, 허지연, 김문석
|
| 소속 |
아주대 |
| 키워드 |
microcapsule; doxorubicin; fluorouracil; cancer
|
| E-Mail |
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