| 학회 | 한국화학공학회 |
| 학술대회 | 2013년 가을 (10/23 ~ 10/25, 대구 EXCO) |
| 권호 | 19권 2호, p.1767 |
| 발표분야 | 열역학 |
| 제목 | Modeling the Phase Behavior in Mixtures of Drugs with Pure Alkanols at Different Temperatures |
| 초록 | The solubility of drugs were measured in 6 alkanols (ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol) at temperature ranging from 278.15 to 318.15 K. The quasi-chemical nonrandom lattice fluid theory (QLF) equation of state (EOS) was applied to calculating solubilities of drugs in alkanols. QLF shows reasonable agreement with experimental data. Activity coefficient approaches were also used for correlation of drugs to compare with EOS approach (QLF). Activity coefficient for solubilities of drugs in alkanols have been calculated by means of the NRTL, UNIQUAC and Wilson equations and with them were correlated solubility data that were compared with the experimental ones. All three correlation results are in good agreement with the experimental data. |
| 저자 | 임준혁1, 신문삼2, 이주호3, 김화용1 |
| 소속 | 1서울대, 2을지대, 3고려대 |
| 키워드 | Mathematical modeling; Phase equilibrium |
| 원문파일 | 초록 보기 |
