| 초록 |
One of the most challenging issues faced by medical industries is maintaining strong adhesion underwater. Marine mussels are known for having strong and durable adhesion strength in rough wet conditions. Mussel foot proteins(Mfps) has a large amount of a unique structure of L-3,4-dihydroxyphenylalanine(DOPA) containing catecholic amino acid. In this study, copolymers with DOPA derivatives, various acrylic monomers and amino-sulfonate zwitterions were synthesized by free radical polymerization to improve the adhesion. Acrylic-grafted block copolymers (PEO-PPO-PEO) with various molecular weight were also successfully prepared. Synthetic bioadhesives were prepared by blending DOPA derivatives with various functional groups, modified block copolymers and various metal ions (Ca2+, Mg2+, Fe3+, V5+). The characteristics of modified DOPA derivatives and block copolymers was evaluated for practical applications. |
