| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
SYNTHESIS OF DUAL RESPONSIVE HYDROGEL VIA DIELS-ALDER CLICK REACTION FOR THE CONTROLLED DELIVERY OF DOXORUBICIN |
| 초록 |
A high drug loading capacity hydrogel for doxorubicin delivery was prepared efficiently by Diels-Alder click chemistry. First, poly(ethylene glycol)-block-poly[styrene-alt-(maleic anhydride)] (PEG-b-PSMA) block copolymers were prepared by the RAFT polymerization. The anhydride groups bearing PSMA moiety were subsequently functionalized with furfuryl amine and hydrazine in a one-pot reaction. Doxorubicin (DOX) was further covalent linked to the block via pH-sensitive hydrazone bond. The Diels-Alder reactions of the furan pendant groups with a disulfide-containing cross-linker resulted in cross-linked hydrogels. The hydrogel loaded DOX showed a high drug loading capacity and efficiency of 15.4% and 85%, respectively. The hydrogel was stable under physiological condition whereas decross-linking took place in reductive acidic environment of tumors leading doxorubicin released rapidly. |
| 저자 |
반욱현, 임권택, 김용훈, Cuong M.Q. Le
|
| 소속 |
부경대 |
| 키워드 |
Diels-Alder click chemistry; hydrogels; doxorubicin; drug delivery
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| E-Mail |
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