| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 |
25권 2호, p.1468 |
| 발표분야 |
생물화공 (Biochemical Engineering) |
| 제목 |
Engineering of Klebsiella oxytoca for improved xylose utilization using Adaptive Laboratory Evolution |
| 초록 |
Lignocellulosic biomass have attracted much attention as a promising renewable resource due to the issues of fossil energy. Lignocellulosic hydrolysates derived from the biomass contain diverse fermentable sugars. Xylose is the second most abundant fermentable pentose after glucose in the hydrolysates. Therefore, enhancement of a xylose fermentation efficiency of microorganisms is a prerequisite for increasing the economic value of producing high-value bio-products using lignocellulosic hydrolysate. Here, we engineered Klebsiella oxytoca for highly efficient production of 2,3-BDO from xylose. Through adaptive laboratory evolution in the media containing xylose, xylose-evolved cells were successfully isolated, which showed much faster cell growth. We concluded that engineered K. oxytoca has considerable potential to be a novel candidate for lignocellulose bioconversion to 2,3-BDO by applying to high concentration of xylose fermentation. |
| 저자 |
차지원, Seung Hoon Jang, 정기준
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| 소속 |
한국과학기술원 |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
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