| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Protease-Activatable Polymersome for the Diagnosis and Treatment of Cancer Metastasis |
| 초록 |
Metastasis-associated proteases, such as MT1-MMP, play decisive roles during malignancy and have been used as biomarkers for diagnosis, prognosis, and drug targeting. Proteases-activatable polymersomes have great potential as cancer theragnosis platform due to the high selectivity of the activating proteases. Here we report a highly modular design for the efficient and simple synthesis of amphiphilic block polymer-peptide and copolypeptide based on methoxy-poly (ethyleneglycol)-b-polyleucine (mPEG-b-pLeu) and MT1-MMP antagonist peptide-b-polyleucine (MT1-peptide-b-pLeu), respectively. These amphiphilic self-assemble in water into polymersomes that can disassemble and release encapsulated imaging agent, gene and drug upon enzymatic activation. Importantly, this system was found to prevent the initiation and progression of cancer metastasis. Consequently, this study may also provide new strategy in the development of nanomedicine for diagnosis and therapy of cancer metastasis. |
| 저자 |
김현욱, 최지혜, 김지혜, 장은지, 강병훈, 임종우, 윤다연, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
Polymesome; MMP; Theragnosis
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| E-Mail |
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