| 초록 |
Molecular imaging using nanoprobes with high resolution and low toxicity is essential in ealry cancer detection. A new class of smart imaging probe employing the PEGylated gold nanorods (GNRs) conjugated with cRGD is introduced for specific optical imaging of αvβ3 integrins from glioblastoma. In order to assess the potential of the cRGD-PGNRs as a targeted imaging probe, we investigated their optical properties, biocompatibility, colloidal stability and in vitro / in vivo binding affinity for cancer cells. Consequently, the glioblastoma images using cRGD-PGNRs demonstrated the excellent tumor targeting ability without cytotoxicity as well as sufficient cellular uptake due to stable and prolonged blood circulation of cRGD-PGNRs. |
