| 초록 |
Here we present a novel, synthetic bacterial system as an immune stimulant composed of three main subdivisions: an outer lipid membrane, a bacterial genomic core, and a polymer interface. The specific decomposition rate of the polymer groups prompted an antigen-triggering response that controls the maturation of dendritic cells. To track the maturation of dendritic cells, several specific surface markers, such as CD80 and CD86, were analyzed with flow cytometry, and the levels of several cytokines secreted from maturated DCs were also measured. Interestingly, the ratio of polylactic-co-glycolic acid to polylactic acid increased from 50:50 to 75:25 during the maturation process. We believe that the synthetic bacteria-based immunostimulation system is a promising therapeutic candidate for several infectious diseases. |
